Creased earlobes and clubbed fingernails are linked to higher heart disease risk. Other risks include halo around the iris and fatty bumps under the skin. https://edition.cnn.com/2018/03/29/health/unusual-heart-disease-signs-partner/index.html
It might be possible to treat the main cause of permanent blindness before people notice any loss of vision, say University College London researchers. http://www.bbc.com/news/health-39725588
